I was on Estrofem 2mg for more than 20+ years with no side effects. I had a historectomy @ age 25 .. 1 year and 9 months after the birth of my twins. I experienced excessive bleeding spells, my gynaecologist did a D&C and other methods different medicines but would not stop. My doctor started treating me with Premarin which caused an allergy and changed it to Estrofem as a result of palpitations and hot flashes. I am now almost 67 had my ovaries removed last year with tumours which was non malignant no cancer. I had a heart valve replacement in 1980. I don't use Estrofem anymore and don't experience hot flashes anymore.
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